Police have closed Highway 19 in both directions at the 42 mile marker.
Traffic is being diverted through Honokaa due to an overturned semi-truck.
The highway is expected to re-open in 1 to 2 hours.
A police spokeswoman said the semi-truck overturned to avoid hitting a car turning left onto the highway from Mamane Street.
Minor injuries have been reported.
Earlier, only the Waimea-bound lane was closed.