Kawaihae Road will remain closed in both directions for several hours after a fuel tanker overturned Friday near the 63- and 64-mile markers.
The truck ran off the road and overturned, killing the driver, police said.
The tanker was carrying 8,400 gallons of diesel fuel. A replacement tanker is at the scene to transfer the fuel.
Motorists are advised to use Waikoloa Road or Kohala Mountain Road until further notice.